{"id":43387,"date":"2021-11-10T09:14:23","date_gmt":"2021-11-10T08:14:23","guid":{"rendered":"https:\/\/www.buchinger-wilhelmi.com\/?p=43387"},"modified":"2025-12-19T09:21:48","modified_gmt":"2025-12-19T08:21:48","slug":"muscle-and-protein-loss-long-term-fasting-study","status":"publish","type":"post","link":"https:\/\/www.buchinger-wilhelmi.com\/en\/muscle-and-protein-loss-long-term-fasting-study\/","title":{"rendered":"Is muscle and protein loss relevant in long-term fasting in healthy men?"},"content":{"rendered":"
[vc_row][vc_column][vc_column_text]THE NEWEST STUDY ON HUMAN LONG-TERM FASTING & MUSCLE LOSS:[\/vc_column_text][vc_empty_space height=”12px”]
\n\t\n\t\t\t

\n\t\t\t\t\t<\/p>\n\t\n\t\n\t

\n\t\tIs muscle and protein loss relevant in long-term fasting in healthy men?\t<\/h2>\n\n\t\n\t\t\n<\/div>[vc_empty_space][\/vc_column][\/vc_row][vc_row css=”.vc_custom_1637308298542{margin-bottom: 30px !important;padding-top: 20px !important;}”][vc_column][vc_column_text]\n

A prospective trial on physiological adaptations<\/h4>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row css=”.vc_custom_1633441047016{margin-bottom: 30px !important;}”][vc_column][vc_column_text]\u00dcberlingen, 10.11.2021 \u2013 Sixteen healthy, non-obese men fasted for ten days according to the Buchinger Wilhelmi fasting programme. This included a daily intake of a protein-free fasting supplement of 200\u2013250 kcal\/day in the form of fruit juices and vegetable broth. The subjects also completed a three-hour moderate exercise programme each day.[\/vc_column_text][\/vc_column][\/vc_row][vc_row css=”.vc_custom_1633441823106{margin-bottom: 30px !important;}”][vc_column][vc_column_text]The average weight loss of 5.9 \u00b1 0.2 kg was explained by the breakdown of fat (40 %), of proteins from metabolically active tissues e.g., liver, kidneys, spleen, intestinal mucosa, heart and skeletal muscles (25 %), of glycogen (8%) and water loss (27 %). Protein sparing mechanisms were triggered after a short time.[\/vc_column_text][\/vc_column][\/vc_row][vc_row content_placement=”middle” css=”.vc_custom_1635874154193{margin-bottom: 30px !important;padding-left: 20px !important;background-color: #ededed !important;}”][vc_column width=”1\/2″][vc_column_text]The study showed that the muscles are less involved than was long feared, and that muscles regenerate after fasting in the same way as other organ tissues.<\/p>\n

No decrease in muscle performance was observed; on the contrary, the performance of the muscles in the lower extremities improved significantly after fasting, while that of the remaining muscles was not affected.[\/vc_column_text][\/vc_column][vc_column width=”1\/2″][vc_single_image image=”43521″ img_size=”large” alignment=”right” onclick=”custom_link” img_link_target=”_blank” css_animation=”fadeIn” link=”https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12766″][\/vc_column][\/vc_row][vc_row css=”.vc_custom_1637316031616{margin-top: 20px !important;margin-bottom: 30px !important;}”][vc_column]

\n\n\t\n\n\t\t\n\t\t\n\t\t\tRead the whole article\t\t<\/span>\n\n\t\t\n\t\t\t<\/a>\n\n<\/div>[\/vc_column][\/vc_row][vc_row css=”.vc_custom_1633441823106{margin-bottom: 30px !important;}”][vc_column][vc_column_text]Protein degradation decreased day by day<\/strong><\/p>\n

Protein breakdown, documented by the negative nitrogen balance, decreased from day to day due to the activation of protein sparing mechanisms. Similarly, 3-methylhistidine, a marker of muscle breakdown, decreased after day 5 of fasting. Other proteolysis markers such as GOT and creatinine confirm this observation. When food was reintroduced after fasting, myostatin decreased\u00a0 significantly, promoting the regeneration of muscle mass.[\/vc_column_text][\/vc_column][\/vc_row][vc_row css=”.vc_custom_1633441823106{margin-bottom: 30px !important;}”][vc_column][vc_column_text]Observations after 3 months fasting program<\/strong><\/p>\n

After three months, the subjects were re-examined. Their general state of health was good. Their body weight was less than before, and their metabolic rate had decreased correspondingly. Values that had increased temporarily during fasting had returned to baseline.[\/vc_column_text][\/vc_column][\/vc_row][vc_row css=”.vc_custom_1639644231206{margin-top: 30px !important;margin-bottom: 30px !important;}”][vc_column][vc_video link=”https:\/\/www.youtube.com\/watch?v=873gQ33G-6U”][vc_empty_space height=”50″][\/vc_column][\/vc_row][vc_row css=”.vc_custom_1633441823106{margin-bottom: 30px !important;}”][vc_column][vc_column_text]Previous and further fasting studies<\/strong><\/p>\n

As shown in previous publications, the Buchinger Wilhelmi fasting programme \u2013 which includes physical activity \u2013 is a safe approach to preventing and treating age-related diseases such as obesity, diabetes mellitus type 2 and other metabolic disorders, as well as chronic inflammatory diseases and oxidative stress.<\/p>\n

For people of an advanced age who are underweight and suffer from degenerative muscle loss, other nutritional strategies \u2013 if therapeutically necessary \u2013 are indicated.<\/p>\n

Further studies are currently being conducted to evaluate to what extent the above mentioned metabolically active tissues are involved in protein utilisation during fasting. Another topic of current research is the regeneration of these protein structures and cells through new synthesis and from stem cells when food is reintroduced.<\/p>\n

Link to the publication: https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12766[\/vc_column_text][\/vc_column][\/vc_row][vc_row css=”.vc_custom_1633441686538{margin-top: 30px !important;}”][vc_column][vc_column_text]Authors<\/strong><\/p>\n

Claire Laurens, Franziska Grundler, Anthony Damiot, Isabelle Chery, Anne-Laure Le Maho, Alexandre Zahariev, Yvon Le Maho, Audrey Bergouignan, Guillemette Gauquelin-Koch, Chantal Simon, St\u00e9phane Blanc, Fran\u00e7oise Wilhelmi de Toledo, <\/em><\/p>\n

\u201cIs muscle and protein loss relevant in long-term fasting in healthy men? A prospective trial on physiological adaptations\u201d, published in Journal of Cachexia, Sarcopenia and Muscle on October 20, 2021<\/em><\/p>\n

doi: 10.1002\/jcsm.12766<\/p>\n

Contact<\/strong><\/p>\n

Dr. Fran\u00e7oise Wilhelmi de Toledo
\nE-Mail: francoise.wilhelmi@buchinger-wilhelmi.com<\/a>[\/vc_column_text][\/vc_column][\/vc_row][vc_row css=”.vc_custom_1633454847795{margin-top: 30px !important;}”][vc_column]

\n\n\t\n\n\t\t\n\t\t\n\t\t\tMore studies, publications and literature\t\t<\/span>\n\n\t\t\n\t\t\t<\/a>\n\n<\/div>[\/vc_column][\/vc_row]\n<\/div>","protected":false},"excerpt":{"rendered":"

A prospective trial in healthy men suggests that during a 10-day Buchinger fast with daily exercise, muscle loss is limited. Find out more!<\/p>\n","protected":false},"author":30,"featured_media":43521,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_custom_body_class":"","_custom_post_class":"","_searchwp_excluded":"","inline_featured_image":false,"footnotes":""},"categories":[184,77,157],"tags":[],"class_list":["post-43387","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-fasten-studien-en","category-news","category-press-releases"],"acf":[],"yoast_head":"\nFasting & muscle loss? - Buchinger Wilhelmi<\/title>\n<meta name=\"description\" content=\"Fasting & muscle loss? In our study, we showed that the muscles are probably less involved than was long feared. 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